Neuroscience Computer Science

PhD Student investigating hippocampal dynamics in active decision making.
Specializing in Calcium Imaging and Computational Analysis.

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About Me

Matthew Cooke

I am a PhD Student in Neuroscience at the University of British Columbia (UBC), working under the supervision of Dr. Jason Snyder. I previously earned my MSc in Neuroscience (UBC) and BSc in Computer Science (McGill University).

My research focuses on probabilistic learning and decision making. I use advanced techniques like in-vivo calcium imaging (Miniscopes) and all-optical interrogation to understand how hippocampal neural ensembles encode choice values in real-time.

Beyond the lab, I am an advocate for Open Science (creator of Pathfinder), a hobbyist in Home Automation, and the founder of 3133 Computing.

4+

Publications

190

Citations

13+

Projects

Technical Skills

Calcium Imaging
Python & ML
Rodent Surgery
Bioinformatics
IT Management
Network Security
Home Assistant

Selected Research & Projects

Hippocampal Dynamics (PhD)

Investigating how neural circuits process task information using single-photon miniscopes and targeted optogenetic manipulation in mice.

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Pathfinder Software

Open-source software for analyzing spatial navigation search strategies. Published in F1000Research.

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Neurogenesis Modeling

Developed mathematical models to trace neuron development, filopodia formation, and bouton development. Published in J. Neuroscience.

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Hippocampal Silencing (MSc)

Investigated the effects of silencing the dorsal and ventral hippocampus using DREADDs during probabilistic reversal learning.

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Algorithmic Pathfinding

Analysis of pathfinding efficiency in modern game environments (A* and similar algorithms).

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3133 Computing

Founder of an IT business providing comprehensive services to help clients stay connected and secure.

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Let's Connect

I'm available for research collaborations and consulting.

Snyder Lab
UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC